CTP Synthetase-IN-1( —— )

Catalog No. M36463 CAS No. 2338811-71-3

CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.

Purity : >98% (HPLC)

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Biological Information

Product Name

CTP Synthetase-IN-1
Note

Research use only, not for human use.
Brief Description

CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.
Description

CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects.
In Vitro

CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively.
In Vivo

CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model.Animal Model:Mouse collagen-induced arthritis (CIA) model Dosage:10 mg/kg and 50 mg/kg Administration:p.o; twice daily; for 18 days Result:Resulted in improvements in specific indicators of disease severity.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

2338811-71-3
Formula Weight

512.53
Molecular Formula

C20H19F3N6O3S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (195.11 mM; Ultrasonic )
SMILES

O=C(NC1=NC=C(C=C1)C2=NC(=CN=C2)C(F)(F)F)C(C=3N=C(SC3)NS(=O)(=O)C4CC4)(C)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Andrew Novak, et al. Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem. 2022 Dec 22;65(24):16640-16650.?

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